Protein name:
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe ;
Alternative:
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules inhibiting Jagged mediated Notch signaling. Essential mediator of somite segmentation and patterning. During somite boundary formation, it restricts Notch activity in the presomitic mesoderm to a boundary-formig territory in the posterior half of the prospective somite. In this region, Notch function activates a set of genes that are involved in boundary formation and in anterior-posterior somite identity. Ectopically expressed in the thymus, Lfgn inhibits Notch signaling which results in inhibition of T-cell commitment and promotes B-cell development in lymphoid progenitors. May play a role in boundary formation of the enamel knot.
Subcellular Location:
Golgi apparatus membrane
Single-pass type II membrane protein
Protein Attributes:
50:
MLQRCGRRLL | LALVGALLAC | LLVLTADPPP | TPMPAERGRR | ALRSLAGSSG |
100:
GAPASGSRAA | VDPGVLTREV | HSLSEYFSLL | TRARRDADPP | PGVASRQGDG |
150:
HPRPPAEVLS | PRDVFIAVKT | TRKFHRARLD | LLFETWISRH | KEMTFIFTDG |
200:
EDEALAKLTG | NVVLTNCSSA | HSRQALSCKM | AVEYDRFIES | GKKWFCHVDD |
250:
DNYVNLRALL | RLLASYPHTQ | DVYIGKPSLD | RPIQATERIS | EHKVRPVHFW |
300:
FATGGAGFCI | SRGLALKMGP | WASGGHFMST | AERIRLPDDC | TIGYIVEALL |
350:
GVPLIRSGLF | HSHLENLQQV | PTTELHEQVT | LSYGMFENKR | NAVHIKGPFS |
378:
VEADPSRFRS | VHCHLYPDTP | WCPRSAIF
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Chicken
Bovine
ELISA Kit for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
ELISA Kit for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
ELISA Kit for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
ELISA Kit for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
ELISA Kit for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
CLIA Kit for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
CLIA Kit for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
CLIA Kit for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
CLIA Kit for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
CLIA Kit for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Polyclonal Antibody for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Polyclonal Antibody for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Polyclonal Antibody for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Polyclonal Antibody for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Polyclonal Antibody for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Monoclonal Antibody for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Monoclonal Antibody for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Monoclonal Antibody for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Monoclonal Antibody for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Monoclonal Antibody for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Protein for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Protein for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Protein for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Protein for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Protein for Mouse Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
"Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila."
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[
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE OF 1-143;DEVELOPMENTAL STAGE
strain :
129S6/SvEvTac .
4.
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Bone marrow .
tissue :
Lung .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEVELOPMENTAL STAGE
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEVELOPMENTAL STAGE
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEVELOPMENTAL STAGE